GABA and glutamate in schizophrenia: A 7 T 1H-MRS study
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چکیده
منابع مشابه
GABA and glutamate in schizophrenia: A 7 T 1H-MRS study
Schizophrenia is characterized by loss of brain volume, which may represent an ongoing pathophysiological process. This loss of brain volume may be explained by reduced neuropil rather than neuronal loss, suggesting abnormal synaptic plasticity and cortical microcircuitry. A possible mechanism is hypofunction of the NMDA-type of glutamate receptor, which reduces the excitation of inhibitory GAB...
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Background The etiology and pathomechanism of schizophrenia are unknown. The traditional dopamine (DA) hypothesis is unable to fully explain its pathology and therapeutics. The glutamate (Glu) and γ-aminobutyric acid (GABA) hypotheses suggest Glu or GABA concentrations are abnormal in the brains of patients with schizophrenia. Magnetic resonance spectroscopy (MRS) show glutamate level increases...
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INTRODUCTION Schizophrenia is a debilitating disease whose phenomenology has long been recognized, but the pathophysiology has only been partially understood. Although multiple brain regions appear to be affected in the disease, there is convergent evidence for hippocampus involvement. Alterations in this area have been documented by both neuroimaging and postmortem studies [1,2]. Based upon ph...
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PURPOSE To assess reproducibility of glutamate measurement in the human brain by two short echo time (TE) 1H-MRS sequences [stimulated echo acquisition mode (STEAM) and semi-localized by adiabatic selective refocusing (sLASER)] at 7 T. Reliable assessment of glutamate is important when studying a variety of neurological and neuropsychiatric disorders. At 7 T, the glutamate signal can be separat...
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BACKGROUND Glutathione (GSH), a major intracellular antioxidant, plays a role in NMDA receptor-mediated neurotransmission, which is involved in the pathophysiology of schizophrenia. In the present study, we aimed to investigate whether GSH levels are altered in the posterior medial frontal cortex of schizophrenic patients. Furthermore, we examined correlations between GSH levels and clinical va...
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ژورنال
عنوان ژورنال: NeuroImage: Clinical
سال: 2014
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2014.10.005